From the wooden bars in a xylophone or the head of a drum, to the strings and sound box of a guitar or violin, musical instruments are the most familiar examples of mechanical resonators. The actual mechanical vibrations of these instruments create acoustic waves that we hear as sound. The purity of the emitted tone is intimately related to the decay of the vibration amplitude, that is, the mechanical losses of the system. A figure of merit for mechanical losses is the quality factor, simply called "Q", which describes the number of oscillations before the amplitude has decayed to a minute fraction of its starting value. The larger Q, the purer the tone and the longer the system will vibrate before the sound damps out. In addition to the aesthetic examples found in a concert hall, mechanical resonators have become increasingly important for a wide variety of advanced technological applications, with such diverse uses as filtering elements in wireless communications systems, timing oscillators for commercial electronics, and cutting-edge research tools which include advanced biological sensors and emerging quantum electro- and optomechanical devices. Rather than producing pleasing acoustics, these applications rely on very "pure" vibrations for isolating a desired signal or for monitoring minute frequency shifts in order to probe external stimuli or to address fundamental questions of quantum physics.